Marked differences exist among NSAIDs in their selective inhibition of the two subtypes of cyclooxygenase, COX-1 and COX-2.
2.
MZB exerts its activity through selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides.
3.
Farinomalein has shown potent and selective inhibition ( 0.15-5 ?g / disk ) against eight isolates of plant pathogenic " Phytophthora sojae ".
4.
Ca v 1.3 channels belong to the Ca v 1 family, which form L-type calcium currents and are sensitive to selective inhibition by dihydropyridines ( DHP ).
5.
May, M . J ., " et al . ", Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.
6.
A para-sulfamoylphenyl at position 1 of the pyrazole was found to have a higher potency for COX-2 selective inhibition than a para-methoxyphenyl ( see structures 1 and 2, below ).
7.
The most significant difference between the isoenzymes, which allows for selective inhibition, is the substitution of isoleucine at position 523 in " COX-1 " with valine in " COX-2 ".
8.
Research indicates that the active site environment of Plasmodium SHMTs ( PSHMTs ) differ from that of human cytosolic SHMT quite a bit, allowing for the possibility of selective inhibition of PSHMT and, thus, the treatment of malaria infections.
9.
The natural chemical farinomalein ( a metabolite from entomopathogenic fungus " Paecilomyces farinosus " ) has shown potent and selective inhibition ( 0.15-5 ?g / disk ) against eight isolates of plant pathogenic " Phytophthora sojae ".
10.
The underlying mechanism for the deleterious effect proposes that endothelial cells lining the microvasculature in the body express COX-2, whose selective inhibition results in levels of prostaglandin I2 ( PGI2, prostacyclin ) down-regulated relative to thromboxane ( since COX-1 in platelets is unaffected ).
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